Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.43 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947286 | 0.82 | PTGS2 (0.46) | HSD11B1ALDH1A1POLBHTTTSHR | |
| SCHEMBL4408728 | 0.78 | ALDH1A1 (0.50) | HSD11B1ALDH1A1POLBHTTTSHR | |
| SCHEMBL9877609 | 0.75 | SMN1; SMN2 (0.51) | TP53ALDH1A1HTTTSHRMAPT | |
| SCHEMBL8947294 | 0.73 | MAPK1 (0.61) | CYP19A1HSD11B1ALDH1A1POLBHTT | |
| SCHEMBL8947258 | 0.72 | MAPT (0.55) | TP53ALOX12CYP19A1SLC5A1SLC5A2 | |
| SCHEMBL8947182 | 0.71 | HSD11B1 (0.65) | CYP19A1HSD11B1ALDH1A1POLBHTT | |
| SCHEMBL12781922 | 0.70 | MGLL (0.51) | CYP19A1HSD11B1ALDH1A1POLBHTT | |
| SCHEMBL25380972 | 0.69 | FGFR3 (0.47) | GABRA2GABRB2ALDH1A1PIN1TSHR | |
| SCHEMBL8947145 | 0.69 | HSD11B1 (0.59) | CYP19A1HSD11B1ALDH1A1POLBHTT | |
| SCHEMBL3100969 | 0.69 | ALDH1A1 (0.51) | TP53ALOX12SLC5A1SLC5A2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |