Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | PTGIR | P43119 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10553872 | 0.93 | ALOX15 (0.51) | ALOX15PTGDR2PTGIRHSD17B10MAPT | |
| SCHEMBL10445943 | 0.92 | ALOX15 (0.50) | ALOX15PTGDR2PTGIRHSD17B10MAPT | |
| SCHEMBL10419697 | 0.90 | ALOX15 (0.48) | ALOX15PTGDR2PTGS2SMN1; SMN2MEN1 | |
| SCHEMBL10414085 | 0.87 | ALOX15 (0.50) | ALOX15PTGDR2PTGIRHSD17B10MAPT | |
| SCHEMBL2375145 | 0.74 | PTGIR (0.57) | PTGIR | |
| SCHEMBL2375142 | 0.74 | PTGIR (0.57) | PTGIR | |
| SCHEMBL12243499 | 0.74 | PTGIR (0.57) | PTGIR | |
| SCHEMBL24076967 | 0.73 | ALOX15 (1.00) | ALOX15MAPTTSHRRAB9ACMA1 | |
| SCHEMBL23399319 | 0.72 | DHFR (0.45) | ALOX15MAPTPTGS2ADORA2ASMN1; SMN2 | |
| SCHEMBL23401417 | 0.70 | HTR2A (0.47) | ALOX15HSD17B10MAPTADORA2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299407-B1 | 1H-PYRAZOLE-1-ALKANAMIDES AND PREPARATION USEFUL AS ANTIARRHYTHMIC AGENTS | STERLING DRUG INC. (US) | 1990-10-24 | — | — | EP | claimed |
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0388654-A2 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |
| US-4870095-A | 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use | STERLING DRUG, INC. (US) | 1989-09-26 | — | — | US | disclosed |