Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.36 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9878600 | 0.79 | MEN1 (0.45) | ALDH1A1HPGDSMN1; SMN2GAAMAPT | |
| SCHEMBL14942690 | 0.76 | HAVCR2 (0.56) | ALDH1A1SMN1; SMN2ALOX15TSHRMAPT | |
| SCHEMBL14029138 | 0.75 | SMN1; SMN2 (0.41) | ALDH1A1HPGDSMN1; SMN2ALOX15TSHR | |
| SCHEMBL1702021 | 0.73 | ALDH1A1 (0.41) | ALDH1A1HPGDSMN1; SMN2GAAMAPT | |
| SCHEMBL10568178 | 0.72 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2ALOX15TSHRMAPT | |
| SCHEMBL9878958 | 0.71 | HPGD (0.57) | ALDH1A1HPGDGAAMAPTLMNA | |
| SCHEMBL3536004 | 0.70 | MAPT (0.65) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA | |
| SCHEMBL7992628 | 0.70 | ALDH1A1 (0.67) | ALDH1A1HPGDSMN1; SMN2TSHRMAPT | |
| SCHEMBL9880004 | 0.70 | ALDH1A1 (0.36) | ALDH1A1HPGDSMN1; SMN2MAPTHTT | |
| SCHEMBL3583064 | 0.70 | MAPT (0.64) | ALDH1A1HPGDSMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018887-A1 | DIAMINOPYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1991-12-12 | — | — | WO | disclosed |