Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 11/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1024806 | 0.81 | KMT2A (0.51) | MEN1KMT2AKDM4ETSHRHTT | |
| SCHEMBL5983793 | 0.78 | PTGS2 (0.49) | MEN1KMT2AKDM4ETSHRGAA | |
| SCHEMBL2980868 | 0.78 | PTGS2 (0.49) | MEN1KMT2AKDM4ETSHRGAA | |
| SCHEMBL8519336 | 0.76 | PTGS2 (0.48) | MEN1KMT2AKDM4ETSHRGAA | |
| SCHEMBL2557627 | 0.76 | TSHR (0.50) | MEN1KMT2AKDM4ETSHRGAA | |
| SCHEMBL2550694 | 0.76 | TSHR (0.50) | MEN1KMT2AKDM4ETSHRGAA | |
| SCHEMBL2552925 | 0.76 | TSHR (0.50) | MEN1KMT2AKDM4ETSHRGAA | |
| SCHEMBL8569987 | 0.76 | TSHR (0.50) | MEN1KMT2AKDM4ETSHRGAA | |
| SCHEMBL8565067 | 0.76 | TSHR (0.50) | MEN1KMT2AKDM4ETSHRGAA | |
| SCHEMBL1745330 | 0.75 | HASPIN (0.46) | MEN1KMT2AKDM4ETSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |