Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9879128 | 0.73 | MEN1 (0.49) | MEN1KMT2AEGFRPIM1CYP3A4 | |
| SCHEMBL9878571 | 0.70 | AXL (0.58) | MEN1KMT2AAXLALDH1A1MAPT | |
| SCHEMBL11022631 | 0.70 | TP53 (0.67) | MEN1KMT2AEGFRPIM1CYP3A4 | |
| SCHEMBL12775753 | 0.70 | ALDH1A1 (0.71) | MEN1KMT2AEGFRPIM1CYP3A4 | |
| SCHEMBL3775165 | 0.69 | PDE4B (0.76) | AXLCYP3A4MAPK1MAPTKDM4E | |
| SCHEMBL7260323 | 0.68 | CRBN (0.48) | AXLCYP3A4MAPK1ALDH1A1MAPT | |
| SCHEMBL11634644 | 0.68 | PDE3A (0.47) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL11797236 | 0.67 | EGFR (0.84) | MEN1KMT2AEGFRPIM1CYP3A4 | |
| SCHEMBL7786291 | 0.67 | MEN1 (1.00) | MEN1KMT2AEGFRPIM1CYP3A4 | |
| SCHEMBL9536843 | 0.67 | MAPT (0.48) | MEN1KMT2AEGFRPIM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991012255-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1991-08-22 | — | — | WO | disclosed |