Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | XBP1 | P17861 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PDE9A | O76083 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9879255 | 0.86 | MEN1 (0.55) | MAPTHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL9878162 | 0.82 | MEN1 (0.52) | MAPTHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL9878778 | 0.81 | ALDH1A1 (0.61) | MAPTHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL9879015 | 0.80 | KMT2A (0.60) | MAPTHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL9878159 | 0.79 | MEN1 (0.52) | MAPTHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL15840587 | 0.77 | MAPT (0.52) | MAPTHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL9879083 | 0.76 | MEN1 (0.56) | MAPTHTTNPSR1SMN1; SMN2LMNA | |
| SCHEMBL9879088 | 0.76 | GAA (0.75) | MAPTHTTSMN1; SMN2LMNAXBP1 | |
| SCHEMBL9776663 | 0.72 | KMT2A (0.65) | MAPTSMN1; SMN2MEN1KMT2APDE9A | |
| SCHEMBL15840770 | 0.72 | MAPT (0.62) | MAPTHTTNPSR1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018887-A1 | DIAMINOPYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1991-12-12 | — | — | WO | disclosed |