Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.34 |
| ▸ | HEXA | P06865 | 3/20 | 0.33 |
| ▸ | HEXB | P07686 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968126 | 0.80 | PDE10A (0.33) | MEN1KMT2AKDM4EGAAMAPT | |
| SCHEMBL19242058 | 0.78 | HEXA (0.47) | MEN1KMT2AHEXAHEXBLMNA | |
| SCHEMBL6962634 | 0.77 | LMNA (0.33) | LMNA | |
| SCHEMBL4287559 | 0.73 | PDE10A (0.44) | HSP90AA1HSP90AB1KDM4EMAPTNPSR1 | |
| SCHEMBL6416401 | 0.72 | DHFR (0.42) | MEN1KMT2AL3MBTL1GHSRHEXA | |
| SCHEMBL11059135 | 0.69 | CCNA2 (0.46) | HSP90AA1HSP90AB1NPSR1PDE10ATRAP1 | |
| SCHEMBL6049603 | 0.69 | DHFR (0.54) | MEN1KMT2AGHSRHEXAHEXB | |
| SCHEMBL6033823 | 0.69 | PDE10A (0.46) | MEN1KMT2AKDM4EGAAMAPT | |
| SCHEMBL20302421 | 0.69 | PDE10A (0.41) | MEN1KMT2AKDM4EGAAMAPT | |
| SCHEMBL27634158 | 0.68 | TDP1 (0.47) | MEN1KMT2AKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018887-A1 | DIAMINOPYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1991-12-12 | — | — | WO | disclosed |