Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9788824 | 0.85 | DRD2 (0.40) | DRD2HTR2AHTR7HTR6 | |
| SCHEMBL9788786 | 0.79 | DRD2 (0.52) | DRD2HTR2AHTR7KCNH2 | |
| SCHEMBL9788754 | 0.76 | DRD2 (0.52) | DRD2HTR2AHTR7HTR6KCNH2 | |
| SCHEMBL9788764 | 0.75 | ACHE (0.46) | — | |
| SCHEMBL9788769 | 0.70 | DRD2 (0.58) | DRD2 | |
| SCHEMBL9788796 | 0.69 | DRD2 (0.56) | DRD2 | |
| SCHEMBL9879857 | 0.67 | DRD3 (0.53) | DRD2HTR2AHTR7HTR6KCNH2 | |
| SCHEMBL11012597 | 0.67 | DRD2 (0.57) | DRD2HTR2AHTR7HTR6 | |
| SCHEMBL11016208 | 0.67 | DRD2 (0.61) | DRD2HTR2AHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL10637651 | 0.67 | DRD2 (0.60) | DRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008264-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-16 | — | — | US | claimed |
| US-5008264-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-16 | — | — | US | disclosed |