Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.56 |
| ▸ | DRD3 | P35462 | 8/20 | 0.56 |
| ▸ | DRD4 | P21917 | 6/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10846357 | 0.89 | DRD2 (0.58) | DRD2DRD3DRD4HTR1A | |
| Hydrochloric Acid SCHEMBL10640317 | 0.88 | DRD2 (0.57) | DRD2DRD3DRD4HTR1APARP1 | |
| Hydrochloric Acid SCHEMBL10845127 | 0.88 | HTR1A (0.59) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9788764 | 0.88 | ACHE (0.46) | — | |
| SCHEMBL9788787 | 0.86 | DRD2 (0.44) | DRD2DRD3DRD4 | |
| SCHEMBL9788754 | 0.83 | DRD2 (0.52) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9788769 | 0.82 | DRD2 (0.58) | DRD2DRD3DRD4 | |
| Oxalic Acid SCHEMBL9788762 | 0.81 | MEN1 (0.45) | DRD2DRD3DRD4 | |
| SCHEMBL9788786 | 0.78 | DRD2 (0.52) | DRD2DRD3DRD4 | |
| Oxalic Acid SCHEMBL9788758 | 0.78 | ALDH1A1 (0.57) | DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008264-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-16 | — | — | US | claimed |
| US-5030639-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-07-09 | — | — | US | disclosed |
| US-5008264-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-16 | — | — | US | disclosed |
| US-4980365-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-12-25 | — | — | US | disclosed |
| EP-0299349-A2 | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-01-18 | — | — | EP | disclosed |