Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9878373 | 0.89 | EGFR (0.46) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL9877831 | 0.86 | HTR1A (0.50) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL9879947 | 0.85 | ALDH1A1 (0.60) | ELANESMN1; SMN2ACHEBCHE | |
| SCHEMBL8996370 | 0.83 | EGFR (0.58) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL9878218 | 0.82 | EGFR (0.54) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL9877341 | 0.79 | EGFR (0.48) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL28440561 | 0.78 | EGFR (0.52) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL9878325 | 0.78 | MEN1 (0.68) | EGFRELANEMEN1KMT2ACTSG | |
| SCHEMBL15413506 | 0.78 | ELANE (0.53) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL11432952 | 0.75 | MEN1 (0.72) | EGFRPIM1ELANEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4966918-A | ANTICARCINOGENIC AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-30 | — | — | US | claimed |
| US-5053431-A | Antitumor-anticarcinogenic agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-10-01 | — | — | US | disclosed |
| US-4966918-A | ANTICARCINOGENIC AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-30 | — | — | US | disclosed |
| WO-1990008759-A1 | DERIVATIVES OF CHRYSOPHANOL | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-08-09 | — | — | WO | disclosed |