Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPP5C | P53041 | 2/20 | 0.49 |
| ▸ | TFPI2 | P48307 | 2/20 | 0.49 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.49 |
| ▸ | NPY4R | P50391 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9880146 | 0.84 | TFPI2 (0.60) | PPP5CTFPI2PPP2CANPY4RHTT | |
| SCHEMBL13001974 | 0.83 | CHRNB2 (0.43) | PPP5CTFPI2PPP2CANPY4RHSD11B1 | |
| SCHEMBL9880162 | 0.83 | PPP5C (0.48) | PPP5CTFPI2PPP2CANPY4RHTT | |
| SCHEMBL9880160 | 0.80 | TSHR (0.54) | PPP5CTFPI2PPP2CANPY4RHTT | |
| SCHEMBL12123980 | 0.80 | TFPI2 (0.46) | PPP5CTFPI2PPP2CANPY4RHTT | |
| SCHEMBL16731268 | 0.75 | PPP5C (0.41) | PPP5CTFPI2PPP2CANPY4RHTT | |
| SCHEMBL9880171 | 0.73 | PPP5C (0.39) | PPP5CTFPI2PPP2CANPY4RHTT | |
| SCHEMBL9881182 | 0.72 | TFPI2 (0.71) | PPP5CTFPI2PPP2CANPY4RHTT | |
| SCHEMBL16731415 | 0.71 | PPARG (0.39) | PPP5CTFPI2PPP2CANPY4RHTT | |
| SCHEMBL3294090 | 0.69 | PPM1B (0.52) | PPP5CTSHRCYP1A2TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329719-B2 | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20120135522-A1 | METHODS OF MODULATING CELL REGULATION BY INHIBITING P53 | LIXTE BIOTECHNOLOGY, INC. | 2012-05-31 | — | — | US | disclosed |
| US-20110287537-A1 | NEUROPROTECTIVE AGENTS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES | LIXTE BIOTECHNOLOGY, INC. | 2011-11-24 | — | — | US | disclosed |
| US-8058268-B2 | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases | LIXTE BIOTECHNOLOGY, INC. (US) | 2011-11-15 | — | — | US | disclosed |