Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.69 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.69 |
| ▸ | CLK2 | P49760 | 2/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.69 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.69 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.69 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.69 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.69 |
| ▸ | PRKX | P51817 | 2/20 | 0.69 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.69 |
| ▸ | CDC7 | O00311 | 1/20 | 0.69 |
| ▸ | PLK4 | O00444 | 1/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.69 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431387 | 0.85 | ROCK2 (0.74) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL9883270 | 0.85 | ROCK2 (0.74) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL1060766 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL13074854 | 0.79 | ROCK2 (0.61) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL12824529 | 0.78 | ROCK2 (0.64) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL9883150 | 0.78 | ROCK2 (0.50) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL14862738 | 0.76 | PLK4 (0.56) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL2564063 | 0.73 | NPC1 (0.68) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL9883271 | 0.73 | ROCK2 (0.69) | ROCK2ROCK1RPS6KB1CLK4SGK2 | |
| SCHEMBL12824530 | 0.72 | ROCK2 (0.67) | ROCK2ROCK1RPS6KB1CLK4SGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135984-A1 | DUAL-ACTION INHBITORS AND METHODS OF USING SAME | AERIE PHARMACEUTICALS, INC. | 2012-05-31 | — | — | US | disclosed |
| WO-2010127330-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHAMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127329-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135984-A1 | DUAL-ACTION INHBITORS AND METHODS OF USING SAME | SLC6A2, ROCK2, SLC6A4 | ROCK2 2/4885ROCK1 6/4885RPS6KB1 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.