Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.64 |
| ▸ | CDC7 | O00311 | 1/20 | 0.64 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.64 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | PAK4 | O96013 | 1/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.64 |
| ▸ | PRKCG | P05129 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.64 |
| ▸ | CDK1 | P06493 | 1/20 | 0.64 |
| ▸ | ROS1 | P08922 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431387 | 0.84 | ROCK2 (0.74) | ROCK2ROCK1CDC7PLK4CHEK1 | |
| SCHEMBL9883270 | 0.84 | ROCK2 (0.74) | ROCK2ROCK1CDC7PLK4CHEK1 | |
| SCHEMBL9883272 | 0.78 | ROCK2 (0.69) | ROCK2ROCK1CDC7PLK4CHEK1 | |
| SCHEMBL1060766 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1CDC7PLK4CHEK1 | |
| SCHEMBL9883271 | 0.74 | ROCK2 (0.69) | ROCK2ROCK1CDC7PLK4CHEK1 | |
| SCHEMBL12824530 | 0.73 | ROCK2 (0.67) | ROCK2ROCK1CDC7PLK4CHEK1 | |
| SCHEMBL2569734 | 0.73 | CTNNB1 (0.63) | ROCK2ROCK1NPC1RAB9AJAK2 | |
| SCHEMBL19699462 | 0.72 | ROCK2 (0.71) | ROCK2ROCK1DYRK3PRKD3MAP4K4 | |
| SCHEMBL23429984 | 0.71 | ROCK2 (0.64) | ROCK2ROCK1CDC7PLK4CHEK1 | |
| SCHEMBL12824525 | 0.71 | ROCK2 (0.69) | ROCK2ROCK1CDC7PLK4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295412-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |