Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990722 | 0.81 | NPY5R (0.46) | ALDH1A1MAPTKDM4EHPGDGLA | |
| SCHEMBL988662 | 0.76 | ALDH1A1 (0.52) | RAB9AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL20320785 | 0.75 | RAB9A (0.44) | RAB9AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL1003932 | 0.72 | ALDH1A1 (0.45) | RAB9AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL990978 | 0.72 | PIK3CA (0.58) | — | |
| SCHEMBL2077039 | 0.70 | ALDH1A1 (0.43) | RAB9AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL2077218 | 0.70 | BRD4 (0.47) | RAB9AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL13562327 | 0.70 | ALDH1A1 (0.45) | RAB9AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL12535899 | 0.70 | PIK3CD (0.47) | RAB9AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL10264401 | 0.69 | ALDH1A1 (0.42) | RAB9AALDH1A1MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |