Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988575 | 0.81 | RAB9A (0.44) | NPY5RMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL8167692 | 0.78 | NFKB1 (0.41) | KDM4EHSD17B10ALDH1A1HPGDALPL | |
| SCHEMBL990978 | 0.76 | PIK3CA (0.58) | PIK3CAPIK3CB | |
| SCHEMBL21358745 | 0.73 | NOTUM (0.44) | NPY5RNOTUMMEN1KMT2AKDM4E | |
| SCHEMBL27706294 | 0.72 | NOTUM (0.47) | NPY5RNOTUMMEN1KMT2AKDM4E | |
| SCHEMBL988659 | 0.71 | NOTUM (0.53) | NPY5RNOTUMMEN1KMT2AKDM4E | |
| SCHEMBL11070942 | 0.71 | KDM4E (0.44) | NPY5RMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22374852 | 0.69 | KDM4E (0.40) | KMT2AKDM4EHSD17B10ALDH1A1HPGD | |
| Chromanone SCHEMBL4474722 | 0.68 | GRM5 (0.55) | NPY5RNOTUMMEN1KMT2AKDM4E | |
| SCHEMBL8913718 | 0.68 | MEN1 (0.42) | NOTUMMEN1KMT2AKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | claimed |
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |