SCHEMBL9889294

SCHEMBL9889294

C=COC(=O)C[PH](=O)C(=O)c1c(C)cc(C)cc1C

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 1/20 0.35
KDM4E B2RXH2 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
HPGD P15428 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NLRP3 Q96P20 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17049713 0.81 KDM4E (0.36) CRHR1KDM4EL3MBTL1MEN1LMNA
SCHEMBL17049710 0.76 KDM4E (0.39) KDM4EL3MBTL1MEN1LMNAHPGD
SCHEMBL17049714 0.74 LMNA (0.36) CRHR1KDM4EL3MBTL1MEN1LMNA
SCHEMBL17049716 0.74 GSTP1 (0.37) KDM4EL3MBTL1NLRP3
SCHEMBL9889297 0.72 CYP3A4 (0.35) KDM4EL3MBTL1MEN1LMNAHPGD
SCHEMBL27963241 0.72 HPGD (0.41) CRHR1KDM4EL3MBTL1MEN1LMNA
SCHEMBL1035454 0.72 KDM4E (0.34) CRHR1KDM4EL3MBTL1MEN1LMNA
SCHEMBL9889322 0.71 CYP3A4 (0.34) KDM4EL3MBTL1MEN1LMNAHPGD
Propene SCHEMBL28249246 0.71 CRHR1 (0.35) CRHR1KDM4EL3MBTL1MEN1LMNA
SCHEMBL1036934 0.71 KDM4E (0.36) CRHR1KDM4EL3MBTL1MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2451847-B1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES IGM GROUP B V (NL) 2021-11-24 EP disclosed
US-9120900-B2 Polymer-bound bisacylphosphine oxides BASF SE (DE) 2015-09-01 US disclosed
US-8883872-B2 Polymer-bound bisacylphosphine oxides BASF SE (DE) 2014-11-11 US disclosed
US-20120142805-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2012-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120142805-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES PHOSPHO1, PARG, PEBP1 CRHR1 4409/4885KDM4E 3616/4885L3MBTL1 1928/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.