Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 16/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.47 |
| ▸ | CD74 | P04233 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4715724 | 0.91 | CTSS (0.55) | CTSSKCNK3CD74 | |
| SCHEMBL1163905 | 0.88 | CTSS (0.54) | CTSSCD74 | |
| SCHEMBL4714854 | 0.88 | CTSS (0.54) | CTSSCD74 | |
| SCHEMBL9889386 | 0.78 | CTSS (0.53) | CTSSCD74 | |
| SCHEMBL4084425 | 0.74 | CTSS (0.49) | CTSSKCNK3 | |
| SCHEMBL2980670 | 0.72 | CREBBP (0.62) | CTSSKCNK3 | |
| SCHEMBL2985059 | 0.72 | CREBBP (0.62) | CTSSKCNK3 | |
| SCHEMBL2972705 | 0.72 | CREBBP (0.62) | CTSSKCNK3 | |
| SCHEMBL4712709 | 0.72 | CREBBP (0.62) | CTSSKCNK3 | |
| SCHEMBL2973788 | 0.70 | KCNK3 (0.68) | CTSSKCNK3CD74 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140179924-A1 | Process for the preparation of cathepsin S inhibitors | JANSSEN PHARMACEUTICA NV (US) | 2014-06-26 | — | — | US | disclosed |
| US-20120142928-A1 | PROCESS FOR THE PREPARATION OF CATHEPSIN S INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179924-A1 | Process for the preparation of cathepsin S inhibitors | CTSS, CTSB, CTSF | CTSS 1/4885KCNK3 4512/4885CD74 880/4885 |
| US-20120142928-A1 | PROCESS FOR THE PREPARATION OF CATHEPSIN S INHIBITORS | CTSS, CTSB, CTSF | CTSS 1/4885KCNK3 4512/4885CD74 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.