Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.57 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | ACP1 | P24666 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9893066 | 0.84 | DYRK1A (0.78) | NPC1RAB9AHTTMAPTDYRK1A | |
| SCHEMBL13390826 | 0.81 | ATAD2 (0.81) | NPC1RAB9ALMNAHTTMAPT | |
| SCHEMBL9891513 | 0.81 | NPC1 (0.57) | NPC1RAB9ALMNAMAPTDYRK1A | |
| SCHEMBL9892912 | 0.81 | RAB9A (0.68) | NPC1RAB9AMAPTDYRK1AFSCN1 | |
| SCHEMBL30553310 | 0.80 | NPC1 (0.74) | NPC1RAB9ALMNAMAPTATAD2 | |
| SCHEMBL9036463 | 0.80 | NPC1 (0.74) | NPC1RAB9ALMNAMAPTATAD2 | |
| SCHEMBL10935898 | 0.80 | DYRK1A (0.59) | NPC1RAB9AMAPTDYRK1AFSCN1 | |
| SCHEMBL11100178 | 0.80 | PPARA (0.57) | DYRK1AFSCN1SMN1; SMN2IDO1FFAR2 | |
| SCHEMBL18851598 | 0.78 | KDM4E (0.63) | NPC1RAB9ALMNAHTTMAPT | |
| SCHEMBL11716373 | 0.77 | MAPT (0.59) | NPC1RAB9AMAPTDYRK1AFSCN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | NPC1 1904/4885RAB9A 2299/4885LMNA 4696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.