SCHEMBL9892568

SCHEMBL9892568

COC(=O)C(=N)c1ccccc1CO/N=C(\C)c1cccc(C(F)(F)F)c1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 2/20 0.48
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
RXFP1 Q9HBX9 7/20 0.42
PPARG P37231 1/20 0.42
PPARA Q07869 1/20 0.42
GAA P10253 1/20 0.41
NPSR1 Q6W5P4 2/20 0.40
ABCB1 P08183 1/20 0.40
TP53 P04637 1/20 0.40
KDM4E B2RXH2 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6068395 0.90 PPARG (0.44) HIF1AMEN1KMT2ARXFP1PPARG
SCHEMBL28465127 0.87 HIF1A (0.64) HIF1AMEN1KMT2ARXFP1PPARG
SCHEMBL29363702 0.87 HIF1A (0.64) HIF1AMEN1KMT2ARXFP1PPARG
SCHEMBL29368184 0.87 HIF1A (0.64) HIF1AMEN1KMT2ARXFP1PPARG
SCHEMBL7960472 0.87 HIF1A (0.64) HIF1AMEN1KMT2ARXFP1PPARG
SCHEMBL2321633 0.87 HIF1A (0.64) HIF1AMEN1KMT2ARXFP1PPARG
SCHEMBL9880011 0.87 HIF1A (0.64) HIF1AMEN1KMT2ARXFP1PPARG
SCHEMBL19148 0.87 HIF1A (0.64) HIF1AMEN1KMT2ARXFP1PPARG
SCHEMBL12635931 0.87 HIF1A (0.64) HIF1AMEN1KMT2ARXFP1PPARG
SCHEMBL4448910 0.87 HIF1A (0.64) HIF1AMEN1KMT2ARXFP1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130303527-A1 Fungicidal Active Substance Combinations Containing Trifloxystrobin BAYER CROPSCIENCE AG (DE) 2013-11-14 US disclosed
EP-1423003-B1 FUNGICIDAL ACTIVE SUBSTANCE COMBINATIONS CONTAINING TRIFLOXYSTROBIN BAYER CROPSCIENCE AG (DE) 2013-03-27 EP disclosed
EP-1962593-B1 FUNGICIDAL ACTIVE COMPOUND COMBINATION BAYER CROPSCIENCE AG (DE) 2013-01-23 EP disclosed
US-20120142528-A1 Methods Employing Fungicidal Active Substance Combinations Containing Trifloxystrobin BAYER CROPSCIENCE AG (DE) 2012-06-07 US disclosed
EP-1956913-B1 FUNGICIDAL ACTIVE INGREDIENT COMBINATION BAYER CROPSCIENCE AG (DE) 2012-01-25 EP disclosed
EP-2329716-A1 Use of fungicidal substance combinations Bayer CropScience AG (DE) 2011-06-08 EP disclosed
EP-2319321-A1 Use of fungicidal combinations of active compounds Bayer CropScience AG (DE) 2011-05-11 EP disclosed
EP-2316268-A1 Fungicidal combinations comprising trifloxystrobin Bayer CropScience AG (DE) 2011-05-04 EP disclosed
EP-2301348-A1 Fungicidal active substance combinations containing trifloxystrobin Bayer CropScience AG (DE) 2011-03-30 EP disclosed
WO-2009059976-A2 METHOD, USE AND AGENT FOR PROTECTING A PLANT AGAINST PHAKOPSORA BASF SE (DE) 2009-05-14 WO disclosed
EP-1755390-B1 FUNGICIDAL ACTIVE SUBSTANCE COMBINATION BAYER CROPSCIENCE AG (DE) 2008-07-09 EP disclosed
WO-2007068367-A1 FUNGICIDAL ACTIVE COMPOUND COMBINATION BAYER CROPSCIENCE AG (DE) 2007-06-21 WO disclosed
WO-2007065580-A1 FUNGICIDAL ACTIVE SUBSTANCE COMBINATION BAYER CROPSCIENCE AG (DE) 2007-06-14 WO disclosed
WO-2007062765-A1 FUNGICIDAL ACTIVE INGREDIENT COMBINATION BAYER CROPSCIENCE AG (DE) 2007-06-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130303527-A1 Fungicidal Active Substance Combinations Containing Trifloxystrobin TREH, MGAM, THOP1 HIF1A 2401/4885MEN1 3966/4885KMT2A 2025/4885
US-20120142528-A1 Methods Employing Fungicidal Active Substance Combinations Containing Trifloxystrobin TREH, THOP1, MGAM HIF1A 2684/4885MEN1 4192/4885KMT2A 2381/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.