Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | FOS | P01100 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | GLA | P06280 | 4/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9895278 | 0.88 | ALDH1A1 (0.46) | CHEK2FOSJUNNFKB1NFKB2 | |
| SCHEMBL456547 | 0.81 | KDM4E (0.39) | CHEK2FOSJUNNFKB1NFKB2 | |
| SCHEMBL9895612 | 0.81 | HSD17B10 (0.45) | KDM4EALDH1A1HPGDHSD17B10RECQL | |
| SCHEMBL24170703 | 0.78 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10RECQL | |
| SCHEMBL7960592 | 0.69 | SMN1; SMN2 (0.60) | NFKB1NFKB2RELAKDM4EALDH1A1 | |
| SCHEMBL1989501 | 0.69 | HSD17B10 (0.56) | CHEK2FOSJUNNFKB1NFKB2 | |
| SCHEMBL9894331 | 0.68 | MAPT (0.56) | NFKB1NFKB2RELAKDM4EALDH1A1 | |
| SCHEMBL4026347 | 0.68 | CDC7 (0.46) | CHEK2FOSJUNNFKB1NFKB2 | |
| SCHEMBL9895127 | 0.68 | CYP1A2 (0.47) | ALDH1A1HPGDHSD17B10GLAMEN1 | |
| SCHEMBL7959390 | 0.68 | KDM4E (0.55) | NFKB1NFKB2RELAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630928-B2 | Intermediates to prepare herbicidal pyrimidone derivatives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-04-25 | — | — | US | disclosed |
| EP-2475654-B1 | HERBICIDAL PYRIMIDONE DERIVATIVES | DU PONT (US) | 2016-12-28 | — | — | EP | disclosed |
| US-20160024020-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | FMC CORPORATION | 2016-01-28 | — | — | US | disclosed |
| US-9187432-B2 | Intermediates to prepare herbicidal pyrimidone derivatives | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150105549-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | FMC CORPORATION | 2015-04-16 | — | — | US | disclosed |
| US-8952024-B2 | Herbicidal pyrimidone derivatives | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-02-10 | — | — | US | disclosed |
| CN-102596933-B | Herbicidal pyrimidone derivatives | DU PONT | 2014-09-17 | — | — | CN | disclosed |
| US-20120149573-A1 | HERBICIDAL BUS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES | FMC CORPORATION | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149573-A1 | HERBICIDAL BUS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES | CBR3, CYP1B1, CBR1 | CHEK2 1986/4885FOS 2007/4885JUN 4149/4885 |
| US-20150105549-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | CBR3, CBR1, MSRB3 | CHEK2 740/4885FOS 3271/4885JUN 4729/4885 |
| US-20160024020-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | CBR3, CBR1, PNPO | CHEK2 743/4885FOS 3153/4885JUN 4704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.