Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | P2RY14 | Q15391 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9895257 | 0.83 | CSNK1D (0.77) | CSNK1DROCK2ROCK1TP53NPC1 | |
| SCHEMBL9896282 | 0.81 | CSNK1D (0.74) | CSNK1DROCK2ROCK1TP53NPC1 | |
| SCHEMBL9895215 | 0.78 | NPC1 (0.44) | CSNK1DTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9897188 | 0.78 | PTPN2 (0.46) | CSNK1DTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1464656 | 0.78 | PTGS2 (0.49) | CSNK1DTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9895818 | 0.77 | PTPN1 (0.45) | CSNK1DTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9895023 | 0.77 | PTPN1 (0.45) | CSNK1DTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9896267 | 0.76 | SMN1; SMN2 (0.42) | CSNK1DTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9895379 | 0.76 | PTPN1 (0.48) | CSNK1DTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16021385 | 0.74 | CSNK1D (0.67) | CSNK1DROCK2ROCK1TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149718-A1 | Amido Compounds | BROTHERTON-PLEISS CHRISTINE E (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149718-A1 | Amido Compounds | BROTHERTON-PLEISS CHRISTINE E (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149718-A1 | Amido Compounds | P2RX7, P2RX3, P2RX2 | CSNK1D 2063/4885ROCK2 4499/4885ROCK1 4416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.