Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.50 |
| ▸ | CFD | P00746 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GGT1 | P19440 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899201 | 0.92 | NR4A2 (0.46) | NR4A2CFDAXLTDP1MAPT | |
| SCHEMBL1010947 | 0.91 | DHODH (0.48) | NR4A2CFDKDM4EACLYTSHR | |
| SCHEMBL9934162 | 0.90 | NR4A2 (0.46) | NR4A2TDP1MAPTMEN1KMT2A | |
| SCHEMBL1009498 | 0.90 | TSHR (0.48) | NR4A2CFDTDP1MAPTKDM4E | |
| SCHEMBL1011786 | 0.89 | DHODH (0.45) | NR4A2MAPTKDM4ELMNAGAA | |
| SCHEMBL3151462 | 0.88 | MAPK8 (0.47) | NR4A2CFDGAAALDH1A1SLC6A3 | |
| SCHEMBL8510685 | 0.88 | PLA2G2A (0.51) | NR4A2MAPTKDM4EBACE1ALDH1A1 | |
| SCHEMBL31435276 | 0.86 | KDM4E (0.46) | MAPTKDM4ELMNAGAATSHR | |
| SCHEMBL1332988 | 0.86 | KDM4E (0.46) | MAPTKDM4ELMNAGAATSHR | |
| SCHEMBL9899615 | 0.86 | PLA2G2A (0.49) | NR4A2TDP1MAPTKDM4EBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9028728-B2 | Photochromic materials that include indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2013086248-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 2013-06-13 | — | — | WO | disclosed |
| US-20120145973-A1 | Photochromic Materials That Include Indeno-Fused Naphthopyrans | TRANSITIONS OPTICAL INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120145973-A1 | Photochromic Materials That Include Indeno-Fused Naphthopyrans | NQO1, INTS6, IPO4 | NR4A2 1023/4885CFD 3057/4885AXL 1870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.