Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899615 | 0.93 | PLA2G2A (0.49) | PLA2G2AMAPK8RXFP1BACE1GABRA1 | |
| SCHEMBL6383895 | 0.93 | BACE1 (0.51) | PLA2G2ABACE1GABRA1GABRG2GABRB3 | |
| SCHEMBL17733151 | 0.89 | ALDH1A1 (0.49) | KDM4ECYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL25876669 | 0.88 | BACE1 (0.44) | PLA2G2AMAPK8RXFP1BACE1NR4A2 | |
| SCHEMBL9899016 | 0.88 | NR4A2 (0.50) | BACE1GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL9934162 | 0.88 | NR4A2 (0.46) | PLA2G2ANR4A2MAPT | |
| SCHEMBL1009498 | 0.87 | TSHR (0.48) | MAPK8GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL31435276 | 0.86 | KDM4E (0.46) | KDM4ECYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL1332988 | 0.86 | KDM4E (0.46) | KDM4ECYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL6169984 | 0.86 | RAB9A (0.40) | PLA2G2AMAPK8KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12247035-B2 | Articles comprising indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2025-03-11 | — | — | US | disclosed |
| CN-113227099-B | Articles comprising indolonaphthopyrans | 光学转变有限公司 | 2025-03-11 | — | — | CN | disclosed |
| EP-3898635-B1 | ARTICLES COMPRISING INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2024-12-04 | — | — | EP | disclosed |
| US-20220064175-A1 | Articles Comprising Indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-03-03 | — | — | US | disclosed |
| CN-113227099-A | Articles comprising indole naphthopyrans | 光学转变有限公司 | 2021-08-06 | — | — | CN | disclosed |
| US-8647538-B2 | Photochromic compounds having at least two photochromic moieties | TRANSITIONS OPTICAL, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| WO-2013078086-A1 | PHOTOCHROMIC COMPOUNDS HAVING AT LEAST TWO PHOTOCHROMIC MOIETIES | TRANSITIONS OPTICAL, INC. (US) | 2013-05-30 | — | — | WO | disclosed |
| US-20120136148-A1 | Photochromic Compounds Having At Least Two Photochromic Moieties | TRANSITIONS OPTICAL, INC. (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064175-A1 | Articles Comprising Indolenaphthopyrans | CDC25B, ACTB, CCNB1 | PLA2G2A 519/4885MAPK8 3421/4885RXFP1 2466/4885 |
| US-20120136148-A1 | Photochromic Compounds Having At Least Two Photochromic Moieties | CRY2, PCNA, MTCL3 | PLA2G2A 2201/4885MAPK8 4168/4885RXFP1 4411/4885 |
| US-12247035-B2 | Articles comprising indolenaphthopyrans | ACTB, CCNB1, HMBS | PLA2G2A 666/4885MAPK8 3641/4885RXFP1 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.