Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.42 |
| ▸ | IDH2 | P48735 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900135 | 0.84 | BCL6 (0.39) | CHRM3BCHEACHEMEN1KMT2A | |
| SCHEMBL9899613 | 0.81 | ROCK2 (0.43) | SLC22A12IDH2CHRM3BCHEACHE | |
| SCHEMBL9915915 | 0.80 | LPAR1 (0.49) | SLC22A12PTGS1PTGS2 | |
| SCHEMBL9899393 | 0.79 | LPAR1 (0.40) | CHRM3BCHEACHE | |
| SCHEMBL9900012 | 0.77 | CHRM3 (0.48) | CHRM3 | |
| SCHEMBL9899562 | 0.75 | BCHE (0.55) | BCHEACHEMEN1KMT2ATRPV1 | |
| SCHEMBL15261910 | 0.69 | LPAR1 (0.45) | SLC22A12GSK3AGSK3B | |
| SCHEMBL9915929 | 0.69 | LPAR1 (0.45) | SLC22A12GSK3AGSK3B | |
| SCHEMBL7112369 | 0.67 | CYP2A6 (0.50) | PTGS1PTGS2 | |
| SCHEMBL27799850 | 0.63 | HSD11B1 (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648714-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | Amira Pharmaceuticals, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078593-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | AMIRA PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |