Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 5/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SCN1A | P35498 | 2/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899776 | 0.79 | IDO1 (0.42) | HRH1HTR2ACYP19A1SLC6A4LMNA | |
| SCHEMBL9899391 | 0.75 | TBXAS1 (0.42) | EPHX2TBXAS1HRH1HTR2ASLC6A2 | |
| SCHEMBL9899643 | 0.75 | TBXAS1 (0.42) | EPHX2TBXAS1HRH1HTR2ASLC6A2 | |
| SCHEMBL4575392 | 0.74 | HRH1 (0.60) | HRH1HTR2ACYP19A1LMNAALDH1A1 | |
| SCHEMBL4706109 | 0.74 | SMN1; SMN2 (0.47) | SLC6A2SLC6A4LMNADRD1SLC6A3 | |
| SCHEMBL14661516 | 0.72 | TRIM24 (0.35) | HIF1AALDH1A1 | |
| SCHEMBL9899903 | 0.71 | HTR2A (0.37) | EPHX2HRH1HTR2ACHRM2SLC6A4 | |
| SCHEMBL9899816 | 0.71 | SLC6A4 (0.42) | HRH1HTR2ASLC6A4LMNASLC6A3 | |
| SCHEMBL3664897 | 0.71 | KCNA5 (0.41) | — | |
| SCHEMBL9900014 | 0.70 | HPGD (0.41) | HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648714-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | Amira Pharmaceuticals, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078593-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | AMIRA PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |