Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899643 | 0.81 | TBXAS1 (0.42) | HRH1HTR2ACYP2C19LMNACYP19A1 | |
| SCHEMBL9899391 | 0.81 | TBXAS1 (0.42) | HRH1HTR2ACYP2C19LMNACYP19A1 | |
| SCHEMBL1134347 | 0.81 | IDO1 (0.47) | IDO1TDO2HRH1HTR2AALDH1A1 | |
| SCHEMBL4575392 | 0.80 | HRH1 (0.60) | HRH1HTR2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL9899903 | 0.80 | HTR2A (0.37) | HRH1HTR2AALDH1A1OPRK1TRPA1 | |
| SCHEMBL9900013 | 0.79 | EPHX2 (0.38) | HRH1HTR2AALDH1A1CYP3A4LMNA | |
| SCHEMBL9899816 | 0.77 | SLC6A4 (0.42) | HRH1HTR2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL5410942 | 0.74 | HRH1 (0.58) | HRH1HTR2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL31357687 | 0.74 | SLC18A3 (0.39) | IDO1TDO2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9900221 | 0.73 | HTR2A (0.37) | HRH1HTR2AALDH1A1TRPA1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648714-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | Amira Pharmaceuticals, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078593-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | AMIRA PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |