Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899643 | 0.88 | TBXAS1 (0.42) | TBXAS1EPHX2LMNAHPGDCYP19A1 | |
| SCHEMBL9899776 | 0.81 | IDO1 (0.42) | LMNACYP19A1SLC6A4CYP2C19HTR2A | |
| SCHEMBL9900013 | 0.75 | EPHX2 (0.38) | TBXAS1EPHX2LMNAHPGDCYP19A1 | |
| SCHEMBL4575392 | 0.73 | HRH1 (0.60) | LMNACYP19A1HTR2AHRH1 | |
| SCHEMBL9899903 | 0.73 | HTR2A (0.37) | EPHX2LMNASLC6A4HTR2AHRH1 | |
| SCHEMBL8775886 | 0.72 | TBXAS1 (0.68) | TBXAS1EPHX2LMNAHPGDCYP19A1 | |
| SCHEMBL8775940 | 0.71 | TBXAS1 (0.71) | TBXAS1EPHX2LMNAHPGDCYP19A1 | |
| SCHEMBL8775878 | 0.71 | TBXAS1 (0.71) | TBXAS1EPHX2LMNAHPGDCYP19A1 | |
| SCHEMBL8775786 | 0.71 | TBXAS1 (0.71) | TBXAS1EPHX2LMNAHPGDCYP19A1 | |
| SCHEMBL9915930 | 0.71 | KDM6B (0.41) | TBXAS1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648714-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | Amira Pharmaceuticals, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078593-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | AMIRA PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |