Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344622 | 0.98 | TSHR (0.57) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL15844498 | 0.86 | TSHR (0.62) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL14456672 | 0.79 | TSHR (0.65) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL24498674 | 0.78 | TSHR (0.68) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL9962277 | 0.78 | TSHR (0.68) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL19259817 | 0.76 | TSHR (0.71) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL8939649 | 0.74 | TSHR (0.57) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL13937389 | 0.73 | ALDH1A1 (0.45) | TSHRSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL4367399 | 0.73 | TSHR (0.71) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL5668217 | 0.72 | TSHR (0.69) | TSHRCYP2C9CYP2C19CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140187795-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-07-03 | — | — | US | claimed |
| WO-2012078210-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | claimed |
| US-20140187795-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140187795-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140187795-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-07-03 | — | — | US | disclosed |
| WO-2012078210-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| US-20110312945-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. | 2011-12-22 | — | — | US | disclosed |
| US-20110312945-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312945-A1 | CRTH2 MODULATORS | HRH2, HRH1, NR1H2 | TSHR 356/4885CYP2C9 3663/4885CYP2C19 2812/4885 |
| US-20140187795-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | NR1H2, NR3C2, ARRB1 | TSHR 296/4885CYP2C9 2355/4885CYP2C19 1673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.