Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939653 | 0.82 | HSD11B1 (0.47) | TSHRKMT2ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL8939603 | 0.81 | TSHR (0.48) | TSHRCYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL8939707 | 0.78 | ALDH1A1 (0.60) | TSHRKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL24498674 | 0.76 | TSHR (0.68) | TSHRCYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL9962277 | 0.76 | TSHR (0.68) | TSHRCYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL11351755 | 0.76 | GAA (0.53) | TSHRKMT2ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL14456672 | 0.74 | TSHR (0.65) | TSHRCYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL9900047 | 0.74 | TSHR (0.59) | TSHRCYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL15844498 | 0.72 | TSHR (0.62) | TSHRCYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL3344622 | 0.72 | TSHR (0.57) | TSHRCYP3A4CYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626369-B1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5523464-A | BONE DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| EP-0626369-A1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-30 | — | — | EP | disclosed |