Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
| ▸ | CD38 | P28907 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18027796 | 0.82 | RAB9A (0.56) | F2RSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL893100 | 0.82 | F2R (0.64) | F2RSMN1; SMN2KMT2AALDH1A1KCNK3 | |
| SCHEMBL18207936 | 0.80 | SORT1 (0.54) | F2RSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL15886276 | 0.78 | BACE1 (0.54) | F2RSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL259238 | 0.78 | KDR (0.72) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL29723905 | 0.78 | KDR (0.72) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL30643208 | 0.78 | KDR (0.72) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL22362607 | 0.78 | F2R (1.00) | F2RKMT2ARXFP1NPC1RAB9A | |
| SCHEMBL10192041 | 0.77 | SMN1; SMN2 (0.76) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL21348779 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649068-A1 | OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012077049-A1 | OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-14 | — | — | WO | disclosed |