Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905747 | 0.77 | KDM4E (0.40) | KMT2AKDM4EMEN1HPGDHSD17B10 | |
| SCHEMBL19160402 | 0.71 | KMT2A (0.37) | KMT2AKDM4EMEN1HPGDHSD17B10 | |
| SCHEMBL6992442 | 0.63 | KMT2A (0.41) | KMT2AKDM4EMEN1HPGDHSD17B10 | |
| SCHEMBL754948 | 0.63 | TDP1 (0.43) | KMT2AKDM4EMEN1HPGDHSD17B10 | |
| SCHEMBL6306880 | 0.62 | GLP1R (0.53) | — | |
| SCHEMBL9925837 | 0.61 | — | — | |
| SCHEMBL9901079 | 0.61 | GLP1R (0.36) | TDP1 | |
| SCHEMBL8938457 | 0.61 | LPO (0.48) | KMT2AKDM4EMEN1HPGDHSD17B10 | |
| SCHEMBL19160376 | 0.61 | AXL (0.41) | KMT2AKDM4EMEN1HPGDHSD17B10 | |
| SCHEMBL8724916 | 0.61 | GCK (0.45) | KMT2AKDM4EMEN1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076966-A1 | SUBSTITUTED THIENO [3,4-B] PYRAZINE COMPOUNDS | LUPIN LIMITED (IN) | 2012-06-14 | — | — | WO | claimed |