Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901214 | 0.87 | KCNH2 (0.42) | SLC6A4PARP1SLC6A2SLC6A3RPLP1 | |
| SCHEMBL9900118 | 0.84 | GPR119 (0.31) | — | |
| SCHEMBL5739332 | 0.81 | EHMT2 (0.35) | TACR1SLC6A4EHMT2MEN1KMT2A | |
| SCHEMBL5738826 | 0.80 | NOS2 (0.33) | TACR1SLC6A4EHMT2SLC6A2SLC6A3 | |
| SCHEMBL4252888 | 0.79 | EHMT2 (0.34) | TACR1SLC6A4EHMT2MEN1KMT2A | |
| SCHEMBL9900276 | 0.79 | SLC6A4 (0.32) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL9901287 | 0.78 | POLB (0.39) | TACR1SLC6A4EHMT2SLC6A2SLC6A3 | |
| SCHEMBL6826820 | 0.76 | SYK (0.35) | KMT2A | |
| SCHEMBL16597711 | 0.75 | NOS2 (0.39) | TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3937268 | 0.75 | PLAT (0.36) | TACR1SLC6A4EHMT2HTR2CPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |