Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.32 |
| ▸ | TACR1 | P25103 | 5/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.31 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739332 | 0.82 | EHMT2 (0.35) | SLC6A4TACR1SLC6A2SLC6A3PIM1 | |
| SCHEMBL5738826 | 0.81 | NOS2 (0.33) | SLC6A4TACR1SLC6A2SLC6A3EHMT2 | |
| SCHEMBL4252888 | 0.80 | EHMT2 (0.34) | SLC6A4TACR1SLC6A2SLC6A3EHMT2 | |
| SCHEMBL9900211 | 0.78 | TACR1 (0.32) | SLC6A4TACR1SLC6A2SLC6A3EHMT2 | |
| SCHEMBL4439402 | 0.78 | POLB (0.49) | POLBHTT | |
| SCHEMBL3937268 | 0.76 | PLAT (0.36) | SLC6A4TACR1EHMT2PLAT | |
| SCHEMBL2348264 | 0.73 | TACR1 (0.42) | SLC6A4TACR1SLC6A2SLC6A3 | |
| SCHEMBL16597711 | 0.72 | NOS2 (0.39) | SLC6A4TACR1SLC6A2SLC6A3 | |
| SCHEMBL5751067 | 0.71 | SLC6A4 (0.34) | SLC6A4SLC6A2SLC6A3PIM1PIM2 | |
| SCHEMBL27884240 | 0.71 | SMN1; SMN2 (0.47) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |