SCHEMBL9900291

SCHEMBL9900291

CCCC1(CCC)c2cc(-c3ccccc3)ccc2-c2c1c1c(c3ccc(OC)cc23)OC(c2ccc(O)cc2)(c2ccc(O)cc2)C=C1

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.33
ABL1 P00519 1/20 0.32
ABCB1 P08183 1/20 0.32
BCR P11274 1/20 0.32
PTPN1 P18031 1/20 0.32
BACE1 P56817 1/20 0.31
HSP90AA1 P07900 1/20 0.31
IDH1 O75874 1/20 0.31
PDE4D Q08499 1/20 0.31
PTGER4 P35408 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29565432 1.00 ESR1 (0.33) ESR1ABL1ABCB1BCRPTPN1
SCHEMBL9898733 0.94 ESR1 (0.34) ESR1ABL1ABCB1BCRPTPN1
SCHEMBL29565715 0.94 ESR1 (0.34) ESR1ABL1ABCB1BCRPTPN1
SCHEMBL23604816 0.92 GAA (0.34) PTPN1
SCHEMBL9926881 0.91 GAA (0.33) PTPN1
SCHEMBL23572578 0.89 KDM4E (0.31) BACE1
SCHEMBL9926882 0.88 ESR1 (0.37) ESR1ABL1ABCB1BCRPTPN1
SCHEMBL30359899 0.88
SCHEMBL15028784 0.87 ESR1 (0.36) ESR1ABL1ABCB1BCRPTPN1
SCHEMBL25600433 0.86 PDK2 (0.32) BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12285922-B2 Method for making photofunctional contact lenses ALCON INC. (CH) 2025-04-29 US claimed
US-12247169-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2025-03-11 US claimed
EP-4313567-B1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC (CH) 2025-01-29 EP claimed
US-11999908-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-06-04 US claimed
US-11945895-B2 Photochromic polydiorganosiloxane vinylic crosslinkers ALCON INC. (CH) 2024-04-02 US claimed
EP-4118134-B1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2024-02-28 EP claimed
EP-4304843-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
EP-4304842-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
US-11833771-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2023-12-05 US claimed
EP-4118134-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS Alcon Inc. (CH) 2023-01-18 EP claimed
US-20220339895-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-10-27 US claimed
WO-2022189941-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-09-15 WO claimed
US-20220283338-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-09-08 US claimed
US-20210371731-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2021-12-02 US claimed
US-20210284778-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2021-09-16 US claimed
US-20210284806-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 US claimed
WO-2021181307-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO claimed
WO-2021181341-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO claimed
US-9028728-B2 Photochromic materials that include indeno-fused naphthopyrans TRANSITIONS OPTICAL, INC. (US) 2015-05-12 US claimed
US-12285922-B2 Method for making photofunctional contact lenses ALCON INC. (CH) 2025-04-29 US disclosed
US-12247169-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2025-03-11 US disclosed
US-12111443-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-10-08 US disclosed
US-11999908-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-06-04 US disclosed
US-11945181-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-04-02 US disclosed
US-11945895-B2 Photochromic polydiorganosiloxane vinylic crosslinkers ALCON INC. (CH) 2024-04-02 US disclosed
EP-4313567-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-02-07 EP disclosed
EP-4304842-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP disclosed
US-11833771-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2023-12-05 US disclosed
EP-4237232-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2023-09-06 EP disclosed
EP-4118134-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS Alcon Inc. (CH) 2023-01-18 EP disclosed
US-20220339895-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-10-27 US disclosed
US-20220283338-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-09-08 US disclosed
WO-2022090967-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-05-05 WO disclosed
US-20220126541-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-04-28 US disclosed
US-20210371731-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2021-12-02 US disclosed
US-20210284778-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2021-09-16 US disclosed
US-20210284806-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 US disclosed
WO-2021181341-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO disclosed
WO-2021181307-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO disclosed
US-9028728-B2 Photochromic materials that include indeno-fused naphthopyrans TRANSITIONS OPTICAL, INC. (US) 2015-05-12 US disclosed
US-9028728-B2 Photochromic materials that include indeno-fused naphthopyrans TRANSITIONS OPTICAL, INC. (US) 2015-05-12 US disclosed
US-9028728-B2 Photochromic materials that include indeno-fused naphthopyrans TRANSITIONS OPTICAL, INC. (US) 2015-05-12 US disclosed
WO-2013086248-A1 PHOTOCHROMIC MATERIALS THAT INCLUDE INDENO-FUSED NAPHTHOPYRANS PPG INDUSTRIES, INC. (US) 2013-06-13 WO disclosed
WO-2013086248-A1 PHOTOCHROMIC MATERIALS THAT INCLUDE INDENO-FUSED NAPHTHOPYRANS PPG INDUSTRIES, INC. (US) 2013-06-13 WO disclosed
US-20120145973-A1 Photochromic Materials That Include Indeno-Fused Naphthopyrans TRANSITIONS OPTICAL INC. (US) 2012-06-14 US disclosed
US-20120145973-A1 Photochromic Materials That Include Indeno-Fused Naphthopyrans TRANSITIONS OPTICAL INC. (US) 2012-06-14 US disclosed
US-20120145973-A1 Photochromic Materials That Include Indeno-Fused Naphthopyrans TRANSITIONS OPTICAL INC. (US) 2012-06-14 US disclosed
US-20120145973-A1 Photochromic Materials That Include Indeno-Fused Naphthopyrans TRANSITIONS OPTICAL INC. (US) 2012-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120145973-A1 Photochromic Materials That Include Indeno-Fused Naphthopyrans NQO1, INTS6, IPO4 ESR1 939/4885ABL1 609/4885ABCB1 1662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.