Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7060894 | 0.91 | NPSR1 (0.54) | NPSR1MAPTPTPN1MEN1KMT2A | |
| SCHEMBL1351134 | 0.87 | LMNA (0.55) | NPSR1MAPTPTPN1MEN1KMT2A | |
| SCHEMBL7633450 | 0.83 | MEN1 (0.57) | NPSR1MAPTPTPN1MEN1KMT2A | |
| SCHEMBL28543544 | 0.82 | LMNA (0.54) | NPSR1MAPTPTPN1MEN1KMT2A | |
| SCHEMBL27930026 | 0.81 | ALDH1A1 (0.51) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18801901 | 0.80 | LMNA (0.51) | NPSR1MAPTPTPN1MEN1KMT2A | |
| SCHEMBL1352270 | 0.80 | ALDH1A1 (0.53) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4657892 | 0.80 | ALDH1A1 (0.53) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4659331 | 0.80 | ALDH1A1 (0.53) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7061549 | 0.79 | NPSR1 (0.48) | NPSR1MAPTPTPN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |