Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA7 | P43166 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.37 |
| ▸ | IAPP | P10997 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | DBH | P09172 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772716 | 0.81 | AKR1B1 (0.52) | PKMIAPPAKR1B1TSHRMAPT | |
| SCHEMBL14743769 | 0.75 | KDM4E (0.49) | THRBPKMAKR1B1GAASMN1; SMN2 | |
| SCHEMBL18840215 | 0.75 | KDM4E (0.49) | THRBPKMAKR1B1GAASMN1; SMN2 | |
| SCHEMBL19733326 | 0.75 | KDM4E (0.49) | THRBPKMAKR1B1GAASMN1; SMN2 | |
| SCHEMBL9901928 | 0.74 | THRB (0.37) | THRBCA12CA1CA2CA7 | |
| SCHEMBL7882828 | 0.73 | THRB (0.50) | THRBCA12CA1CA2CA7 | |
| SCHEMBL9900602 | 0.73 | THRB (0.52) | THRBPKMCA12CA1CA2 | |
| SCHEMBL9904604 | 0.73 | THRB (0.52) | THRBPKMCA12CA1CA2 | |
| SCHEMBL9900604 | 0.71 | THRB (0.37) | THRBCA12CA1CA2CA7 | |
| SCHEMBL9904501 | 0.71 | CA12 (0.47) | THRBPKMCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |