Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.36 |
| ▸ | IAPP | P10997 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900406 | 0.82 | PTPN1 (0.41) | MAOBALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL18840201 | 0.76 | ALDH1A1 (0.47) | MAOBALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL19433080 | 0.76 | ALDH1A1 (0.47) | MAOBALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL2044977 | 0.71 | ALDH1A1 (0.32) | ALDH1A1KDM4EPOLBTDP1MAPT | |
| SCHEMBL2044976 | 0.71 | ALDH1A1 (0.32) | ALDH1A1KDM4EPOLBTDP1MAPT | |
| SCHEMBL9900443 | 0.71 | THRB (0.38) | THRBCA12CA1CA2CA7 | |
| SCHEMBL15347875 | 0.71 | POLB (0.41) | ALDH1A1POLBHPGDL3MBTL1CYP3A4 | |
| SCHEMBL6983487 | 0.71 | POLB (0.41) | ALDH1A1POLBHPGDL3MBTL1CYP3A4 | |
| SCHEMBL9900768 | 0.70 | CA2 (0.36) | THRBCA12CA1CA2CA7 | |
| SCHEMBL6981876 | 0.70 | IDO1 (0.40) | MAOAMAOBALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |