Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772705 | 0.77 | AKR1B1 (0.52) | POLBCA2CA12HIF1ACA9 | |
| SCHEMBL9900443 | 0.74 | THRB (0.38) | THRBALDH1A1CA2LMNACA1 | |
| SCHEMBL7882828 | 0.73 | THRB (0.50) | THRBALDH1A1CA2LMNAHPGD | |
| SCHEMBL7962013 | 0.70 | GAA (0.50) | POLBALDH1A1NPC1KMT2AKDM4E | |
| SCHEMBL3658960 | 0.68 | CTBP2 (0.52) | POLBALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL10177334 | 0.68 | CTBP2 (0.52) | POLBALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14667472 | 0.68 | CTBP2 (0.52) | POLBALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28715269 | 0.67 | AKR1B1 (0.44) | THRBPOLBALDH1A1CA2LMNA | |
| SCHEMBL28007823 | 0.67 | CTBP2 (0.52) | ALDH1A1CA2LMNASMN1; SMN2GAA | |
| SCHEMBL68691 | 0.66 | GABRA1 (0.48) | THRBPOLBALDH1A1CA2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |