Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901212 | 0.94 | OPRK1 (0.45) | MAPTLMNAOPRK1CTSSCAPN1 | |
| SCHEMBL9900085 | 0.94 | MAPT (0.38) | MAPTLMNAOPRK1CTSSCAPN1 | |
| SCHEMBL9900633 | 0.93 | LMNA (0.46) | MAPTLMNAOPRK1CTSSCAPN1 | |
| SCHEMBL9900575 | 0.93 | LMNA (0.46) | MAPTLMNAOPRK1CTSSCAPN1 | |
| SCHEMBL9900082 | 0.88 | LMNA (0.41) | MAPTLMNAOPRK1CTSSCAPN1 | |
| SCHEMBL9900018 | 0.82 | OPRK1 (0.44) | MAPTOPRK1GAACYP2C9CYP2C19 | |
| SCHEMBL9900285 | 0.81 | PTGER4 (0.42) | OPRK1CTSS | |
| SCHEMBL9900103 | 0.79 | PTGER4 (0.40) | CTSS | |
| SCHEMBL9901274 | 0.78 | OPRK1 (0.60) | OPRK1 | |
| SCHEMBL9901382 | 0.78 | CYP3A4 (0.43) | MAPTOPRK1KDM4ECYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649061-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Rottapharm S.p.A. (IT) | 2013-10-16 | — | — | EP | claimed |
| WO-2012076063-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ROTTAPHARM S.P.A. (IT) | 2012-06-14 | — | — | WO | claimed |