Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900575 | 1.00 | LMNA (0.46) | LMNAMAPTCTSSCAPN1HSD11B1 | |
| SCHEMBL9900082 | 0.93 | LMNA (0.41) | LMNAMAPTCTSSCAPN1HSD11B1 | |
| SCHEMBL9900634 | 0.93 | MAPT (0.42) | LMNAMAPTCTSSCAPN1HSD11B1 | |
| SCHEMBL9901212 | 0.92 | OPRK1 (0.45) | LMNAMAPTCTSSCAPN1HSD11B1 | |
| SCHEMBL9900085 | 0.87 | MAPT (0.38) | LMNAMAPTCTSSCAPN1HSD11B1 | |
| SCHEMBL9900285 | 0.86 | PTGER4 (0.42) | CTSSPTGER4PTGDROPRK1 | |
| SCHEMBL9923484 | 0.83 | PTGER4 (0.45) | PTGER4PTGDROPRK1SLC6A9SCN10A | |
| SCHEMBL9900684 | 0.83 | SCN9A (0.45) | MAPTHSD11B1PTGER4PTGDRSLC6A9 | |
| SCHEMBL9900804 | 0.82 | PTGER4 (0.41) | PTGER4PTGDR | |
| SCHEMBL9900015 | 0.81 | CTSS (0.43) | CTSSPTGER4PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649061-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Rottapharm S.p.A. (IT) | 2013-10-16 | — | — | EP | claimed |
| WO-2012076063-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ROTTAPHARM S.P.A. (IT) | 2012-06-14 | — | — | WO | claimed |