Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | RXRG | P48443 | 2/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 5/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.41 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1167379 | 0.87 | PIN1 (0.54) | RXRARXRBRXRGHCRTR1HCRTR2 | |
| SCHEMBL1705856 | 0.85 | HCRTR1 (0.46) | RXRARXRBRXRGSLC9A1HCRTR1 | |
| SCHEMBL13056642 | 0.83 | BRD4 (0.43) | HCRTR1HCRTR2FPR2IKBKB | |
| SCHEMBL4738316 | 0.81 | TARBP2 (0.48) | RXRARXRBRXRGFPR2NR4A2 | |
| SCHEMBL13056643 | 0.80 | PARP1 (0.49) | PARP1 | |
| SCHEMBL18084238 | 0.78 | FPR2 (0.45) | RXRARXRBRXRGSLC9A1HCRTR1 | |
| SCHEMBL13056624 | 0.77 | IKBKB (0.44) | IKBKB | |
| SCHEMBL3822883 | 0.77 | RIPK2 (0.46) | RXRARXRBRXRGSLC9A1PARP1 | |
| SCHEMBL13056696 | 0.77 | IKBKB (0.41) | IKBKB | |
| SCHEMBL11621589 | 0.77 | SLC9A1 (0.66) | SLC9A1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649068-A1 | OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012077049-A1 | OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-14 | — | — | WO | disclosed |