SCHEMBL990076

SCHEMBL990076

O=C(O)C1C=Cc2ccccc2O1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 3/20 0.40
HPGD P15428 2/20 0.40
POLB P06746 3/20 0.39
CASP6 P55212 2/20 0.39
CYP2C9 P11712 2/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
SMN1; SMN2 Q16637 3/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
NPSR1 Q6W5P4 2/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
CYP3A4 P08684 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
MAPK1 P28482 1/20 0.32
P2RY6 Q15077 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29366932 1.00 KDM4E (0.40) KDM4EALDH1A1HPGDPOLBCASP6
SCHEMBL28806661 1.00 KDM4E (0.40) KDM4EALDH1A1HPGDPOLBCASP6
Hydrochloric Acid SCHEMBL6994200 0.98 ALDH1A1 (0.39) KDM4EALDH1A1HPGDPOLBCASP6
SCHEMBL9319851 0.87 HPGD (0.37) KDM4EALDH1A1HPGDPOLBCASP6
SCHEMBL9319861 0.87 HPGD (0.37) KDM4EALDH1A1HPGDPOLBCASP6
SCHEMBL11786875 0.86 CYP2B6 (0.34) KDM4EALDH1A1HPGDPOLBCASP6
SCHEMBL3116614 0.85 KDM4E (0.35) KDM4EALDH1A1HPGDPOLBCASP6
SCHEMBL4410965 0.85 ATM (0.41) KDM4EALDH1A1HPGDCYP2C9MEN1
SCHEMBL29696802 0.85 ATM (0.41) KDM4EALDH1A1HPGDCYP2C9MEN1
SCHEMBL9637047 0.85 KDM4E (0.35) KDM4EALDH1A1HPGDPOLBCASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 231 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116124950-B Serum biomarker for growth hormone injection screening or detection and application thereof 复旦大学 2025-02-21 CN claimed
CN-112939963-B Benzopyranoate derivative and synthesis method and application thereof 山西大学 2022-09-23 CN claimed
CN-112939963-A Benzopyranoic acid ester derivative and synthesis method and application thereof 山西大学 2021-06-11 CN claimed
CN-107929743-A Treat the high penetrating power prodrugs composition and medical composition of pulmonary disease 苏州泰飞尔医药有限公司 2018-04-20 CN claimed
CN-107250189-A Crosslinking polydiene propylamine copolymer for treating diabetes B 建新公司 2017-10-13 CN claimed
CN-101092415-B Compound of new benzo heterocycle categories, preparation method and application SHANGHAI INST MATERIA MEDICA 2011-04-27 CN claimed
CN-101092415-A Compound of new benzo heterocycle categories, preparation method and application SHANGHAI INST OF MEDICINES C A (CN) 2007-12-26 CN claimed
US-7141599-B2 Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor, a leukotriene B4 receptor inhibitor and a cyclosporin PHARMACIA CORPORATION (US) 2006-11-28 US claimed
CN-1196692-C Substituted benzopyran derivatives for the treatment of inflammation SEARLE & CO (US) 2005-04-13 CN claimed
CN-1515566-A Substituted chromene derivative for curing inflammation G.D. 2004-07-28 CN claimed
CN-1257489-A Substituted benzopyran derivatives for the treatment of inflammation SEARLE & CO (US) 2000-06-21 CN claimed
EP-0977748-A1 SUBSTITUTED BENZOPYRAN DERIVATIVES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 2000-02-09 EP claimed
WO-1998047890-A1 SUBSTITUTED BENZOPYRAN DERIVATIVES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1998-10-29 WO claimed
EP-0635010-B1 NOVEL CARDIOPROTECTIVE AGENTS MERRELL PHARMA INC (US) 1996-12-11 EP claimed
EP-0331078-A2 Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1989-09-06 EP claimed
US-12496305-B2 Detection for determining corticosteroid responsiveness THE CLEVELAND CLINIC FOUNDATION (US) 2025-12-16 US disclosed
CN-116124950-B Serum biomarker for growth hormone injection screening or detection and application thereof 复旦大学 2025-02-21 CN disclosed
CN-85105645-A The method for making of 1-benzopyran derivatives 1987-01-28 CN disclosed
US-4117134-A 4,5-DIHYDRO-4,5-DIOXO-1H-1-BENZOPYRANO (2,3-B)-PYRIDINE-3-CARBOXYLIC ACIDS, SALTS AND ESTERS WARNER-LAMBERT COMPANY (US) 1978-09-26 US disclosed
US-3952104-A Benzopyran-2-carboxylic acids in the prevention of asthmatic symptoms FISONS LIMITED (EN) 1976-04-20 US disclosed