Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29457182 | 0.90 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBL3MBTL1GLAGPR174 | |
| SCHEMBL9750660 | 0.90 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBL3MBTL1GLAGPR174 | |
| SCHEMBL5785927 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2POLBL3MBTL1HSD17B10LMNA | |
| SCHEMBL5784873 | 0.82 | L3MBTL1 (0.61) | SMN1; SMN2POLBL3MBTL1GLAGPR174 | |
| SCHEMBL10158674 | 0.81 | GPR174 (0.41) | SMN1; SMN2POLBL3MBTL1GLAGPR174 | |
| SCHEMBL10870502 | 0.80 | MEN1 (0.45) | SMN1; SMN2POLBL3MBTL1GLAGPR174 | |
| SCHEMBL14690371 | 0.79 | MBTPS1 (0.48) | SMN1; SMN2POLBL3MBTL1GLAGPR174 | |
| SCHEMBL8390273 | 0.78 | GAA (0.55) | SMN1; SMN2L3MBTL1GPR174HSD17B10ALDH1A1 | |
| SCHEMBL5786743 | 0.78 | NOTUM (0.51) | SMN1; SMN2POLBGLAALDH1A1LMNA | |
| SCHEMBL28012013 | 0.78 | MAPT (0.55) | SMN1; SMN2L3MBTL1MAPTHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788339-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2014-10-15 | — | — | EP | disclosed |
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2013083994-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2013-06-13 | — | — | WO | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |