Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | LIPE | Q05469 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750660 | 0.87 | SMN1; SMN2 (0.48) | MAPTL3MBTL1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL29457182 | 0.87 | SMN1; SMN2 (0.48) | MAPTL3MBTL1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL1229367 | 0.82 | PTGS1 (0.61) | MAPTL3MBTL1LTA4HCYP2C19SMN1; SMN2 | |
| SCHEMBL339812 | 0.80 | MAPT (0.71) | MAPTTDP1L3MBTL1MAPK1LIPE | |
| SCHEMBL5784873 | 0.79 | L3MBTL1 (0.61) | MAPTTDP1L3MBTL1HTTCYP2C19 | |
| SCHEMBL5785927 | 0.79 | SMN1; SMN2 (0.61) | MAPTTDP1L3MBTL1MAPK1HTT | |
| SCHEMBL8380993 | 0.79 | HTT (0.59) | MAPTTDP1L3MBTL1MAPK1HTT | |
| Formaldehyde SCHEMBL27831678 | 0.78 | MAPT (0.63) | MAPTTDP1L3MBTL1MAPK1LIPE | |
| SCHEMBL27276089 | 0.78 | BRD4 (0.55) | MAPTTDP1L3MBTL1MAPK1LIPE | |
| SCHEMBL9901000 | 0.78 | SMN1; SMN2 (0.42) | MAPTL3MBTL1MAPK1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102153562-B | Spiro-oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC | 2015-05-13 | — | — | CN | disclosed |