Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901669 | 0.93 | MAOB (0.35) | MAOBMAOATHRATHRBMAPT | |
| SCHEMBL9901763 | 0.93 | MAOB (0.35) | MAOBMAOATHRATHRBMAPT | |
| SCHEMBL9901647 | 0.92 | MAOB (0.35) | MAOBMAOATHRATHRBMAPK14 | |
| SCHEMBL9905063 | 0.87 | GRM5 (0.31) | — | |
| SCHEMBL9110080 | 0.87 | MAPK14 (0.46) | MAOBMAOAMAPK14 | |
| SCHEMBL9901821 | 0.86 | THRA (0.34) | MAOBMAOATHRATHRBMAPK14 | |
| SCHEMBL9905458 | 0.86 | MAPK14 (0.31) | MAPK14 | |
| SCHEMBL9902538 | 0.85 | MAOB (0.36) | MAOBMAOAMAPT | |
| SCHEMBL9901769 | 0.84 | MAOB (0.36) | MAOBMAOATHRATHRBMAPT | |
| SCHEMBL9905118 | 0.84 | MAOB (0.37) | MAOBMAOATHRATHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | claimed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | claimed |
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |