Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905118 | 0.93 | MAOB (0.37) | MAOBMAOATHRATHRBLMNA | |
| SCHEMBL9901763 | 0.92 | MAOB (0.35) | MAOBMAOATHRATHRBBRD4 | |
| SCHEMBL9901304 | 0.91 | MAOB (0.37) | MAOBMAOAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9901647 | 0.91 | MAOB (0.35) | MAOBMAOATHRATHRBACHE | |
| SCHEMBL9905679 | 0.87 | MAPK14 (0.38) | ALDH1A1LMNACYP1A2CYP3A4GRM5 | |
| SCHEMBL9901297 | 0.86 | BRD4 (0.31) | BRD4GRM5 | |
| SCHEMBL9901669 | 0.85 | MAOB (0.35) | MAOBMAOATHRATHRBALDH1A1 | |
| SCHEMBL9109833 | 0.85 | MAPKAPK2 (0.38) | MAOBMAOAALDH1A1LMNACYP1A2 | |
| SCHEMBL9901007 | 0.84 | MAOB (0.34) | MAOBMAOATHRATHRBMAPT | |
| SCHEMBL9112100 | 0.82 | MAPK14 (0.37) | MAOBMAOAACHEMRGPRX4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |