Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900770 | 0.81 | NPC1 (0.40) | SLC6A4SLC6A2SLC6A3TACR1NPC1 | |
| SCHEMBL2220667 | 0.75 | HRH3 (0.38) | POLBHCAR2HRH3CHRNB2CHRNA4 | |
| SCHEMBL8553350 | 0.72 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3ALDH1A1NPC1 | |
| SCHEMBL4441427 | 0.70 | POLB (0.57) | POLBHCAR2ALDH1A1NPC1RAB9A | |
| SCHEMBL27369328 | 0.69 | CHRM2 (0.47) | SLC6A4SLC6A2SLC6A3TACR1CHRM3 | |
| SCHEMBL15367167 | 0.69 | POLB (0.40) | POLBHCAR2ALDH1A1NPC1RAB9A | |
| SCHEMBL2349391 | 0.69 | TACR1 (0.44) | SLC6A4SLC6A2SLC6A3TACR1QPCT | |
| SCHEMBL3507485 | 0.67 | POLB (0.48) | POLBHCAR2ALDH1A1NPC1RAB9A | |
| SCHEMBL12504878 | 0.67 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4997661 | 0.67 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |