SCHEMBL9900770

SCHEMBL9900770

CC(C)(C)OC(=O)N(c1cncc(Br)c1)C1CCNCC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
GPR119 Q8TDV5 2/20 0.34
UCHL1 P09936 1/20 0.34
USP30 Q70CQ3 1/20 0.34
TACR1 P25103 5/20 0.33
SLC6A4 P31645 3/20 0.33
TAS1R3 Q7RTX0 2/20 0.33
TAS1R1 Q7RTX1 2/20 0.33
TAS1R2 Q8TE23 2/20 0.33
QPCT Q16769 1/20 0.33
CACNA1I Q9P0X4 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A3 Q01959 1/20 0.32
PLAT P00750 1/20 0.32
RORC P51449 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28952936 0.82 TACR1 (0.40) NPC1RAB9ASMN1; SMN2TACR1SLC6A4
SCHEMBL9901055 0.81 POLB (0.38) NPC1RAB9ASMN1; SMN2TACR1SLC6A4
SCHEMBL30502020 0.80 GPR119 (0.40) RAB9AGPR119TACR1SLC6A4SLC6A2
SCHEMBL2355008 0.79 TACR1 (0.34) TACR1SLC6A4QPCTSLC6A2SLC6A3
SCHEMBL12469312 0.76 SLC6A2 (0.46) NPC1RAB9ASMN1; SMN2TACR1SLC6A4
SCHEMBL29935256 0.76 POLB (0.42) NPC1RAB9ASMN1; SMN2UCHL1USP30
SCHEMBL1180489 0.76 POLB (0.42) NPC1RAB9ASMN1; SMN2UCHL1USP30
SCHEMBL17560116 0.75 TACR1 (0.41) TACR1SLC6A4SLC6A2SLC6A3
SCHEMBL9900211 0.74 TACR1 (0.32) TACR1SLC6A4QPCTSLC6A2SLC6A3
SCHEMBL13188227 0.74 RAB9A (0.39) NPC1RAB9ASMN1; SMN2UCHL1USP30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2742046-A1 PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE F.HOFFMANN-LA ROCHE AG (CH) 2014-06-18 EP disclosed
EP-2649065-A1 BICYCLIC COMPOUNDS AS PIM INHIBITORS Amgen Inc. (US) 2013-10-16 EP disclosed
WO-2013024002-A1 PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE F. HOFFMANN-LA ROCHE AG (CH) 2013-02-21 WO disclosed
WO-2012078777-A1 BICYCLIC COMPOUNDS AS PIM INHIBITORS AMGEN INC. (US) 2012-06-14 WO disclosed