Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 19/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990100 | 0.85 | GRM5 (0.47) | GRM5 | |
| SCHEMBL990750 | 0.81 | GRM5 (0.56) | GRM5 | |
| SCHEMBL991609 | 0.80 | GRM5 (0.46) | GRM5 | |
| SCHEMBL989481 | 0.79 | GRM5 (0.47) | GRM5 | |
| SCHEMBL990155 | 0.79 | GRM5 (0.47) | GRM5 | |
| SCHEMBL990050 | 0.78 | ALDH1A1 (0.48) | GRM5ALDH1A1 | |
| SCHEMBL991105 | 0.78 | ALDH1A1 (0.48) | GRM5ALDH1A1 | |
| SCHEMBL990906 | 0.78 | GRM5 (0.46) | GRM5 | |
| SCHEMBL990930 | 0.78 | GRM5 (0.47) | GRM5NPC1RAB9A | |
| SCHEMBL991428 | 0.78 | GRM5 (0.47) | GRM5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137206-A1 | PREDICTIVE MARKERS USEFUL IN THE TREATMENT OF FRAGILE X SYNDROME (FXS) | NOVARTIS AG (CH) | 2011-11-03 | — | — | WO | disclosed |
| EP-2320892-A2 | COMBINATION PRODUCTS | Novartis AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |