Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377251 | 0.86 | ALDH1A1 (0.43) | GRM5NPC1RAB9A | |
| SCHEMBL990340 | 0.85 | L3MBTL1 (0.59) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL992719 | 0.85 | GRM5 (0.47) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990125 | 0.84 | GRM5 (0.57) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL3284072 | 0.84 | GRM5 (0.57) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990817 | 0.83 | GRM5 (0.60) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL989485 | 0.83 | GRM5 (0.47) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990851 | 0.83 | GRM5 (0.46) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990840 | 0.83 | GRM5 (0.60) | GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL990821 | 0.83 | GRM5 (0.44) | GRM5ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137206-A1 | PREDICTIVE MARKERS USEFUL IN THE TREATMENT OF FRAGILE X SYNDROME (FXS) | NOVARTIS AG (CH) | 2011-11-03 | — | — | WO | disclosed |
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |